Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge

The use of adenoviruses (Ad) as vaccine vectors against a variety of pathogens has demonstrated their capacity to elicit strong antibody and cell-mediated immune responses. Adenovirus serotype C vectors, such as Ad serotype 5 (Ad5), expressing Ebolavirus (EBOV) glycoprotein (GP), protect completely...

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Detalhes bibliográficos
Main Authors: Geisbert, Thomas W., Bailey, Michael, Hensley, Lisa, Asiedu, Clement, Geisbert, Joan, Stanley, Daphne, Honko, Anna, Johnson, Joshua, Mulangu, Sabue, Pau, Maria Grazia, Custers, Jerome, Vellinga, Jort, Hendriks, Jenny, Jahrling, Peter, Roederer, Mario, Goudsmit, Jaap, Koup, Richard, Sullivan, Nancy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126236/
https://ncbi.nlm.nih.gov/pubmed/21325402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02407-10
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