Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge

The use of adenoviruses (Ad) as vaccine vectors against a variety of pathogens has demonstrated their capacity to elicit strong antibody and cell-mediated immune responses. Adenovirus serotype C vectors, such as Ad serotype 5 (Ad5), expressing Ebolavirus (EBOV) glycoprotein (GP), protect completely...

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Hlavní autoři: Geisbert, Thomas W., Bailey, Michael, Hensley, Lisa, Asiedu, Clement, Geisbert, Joan, Stanley, Daphne, Honko, Anna, Johnson, Joshua, Mulangu, Sabue, Pau, Maria Grazia, Custers, Jerome, Vellinga, Jort, Hendriks, Jenny, Jahrling, Peter, Roederer, Mario, Goudsmit, Jaap, Koup, Richard, Sullivan, Nancy J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126236/
https://ncbi.nlm.nih.gov/pubmed/21325402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02407-10
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