A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

This study describes a tumor progression model for ductal pancreatic cancer in mice overexpressing TGF-α. Activation of Ras and Erk causes induction of cyclin D1-Cdk4 without increase of cyclin E or PCNA in ductal lesions. Thus, TGF-α is able to promote progression throughout G(1), but not S phase....

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Bibliografiske detaljer
Main Authors: Wagner, Martin, Greten, Florian R., Weber, Christoph K., Koschnick, Stefan, Mattfeldt, Torsten, Deppert, Wolfgang, Kern, Horst, Adler, Guido, Schmid, Roland M.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC312620/
https://ncbi.nlm.nih.gov/pubmed/11159909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.184701
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