A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

This study describes a tumor progression model for ductal pancreatic cancer in mice overexpressing TGF-α. Activation of Ras and Erk causes induction of cyclin D1-Cdk4 without increase of cyclin E or PCNA in ductal lesions. Thus, TGF-α is able to promote progression throughout G(1), but not S phase....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wagner, Martin, Greten, Florian R., Weber, Christoph K., Koschnick, Stefan, Mattfeldt, Torsten, Deppert, Wolfgang, Kern, Horst, Adler, Guido, Schmid, Roland M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2001
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC312620/
https://ncbi.nlm.nih.gov/pubmed/11159909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.184701
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados