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A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
This study describes a tumor progression model for ductal pancreatic cancer in mice overexpressing TGF-α. Activation of Ras and Erk causes induction of cyclin D1-Cdk4 without increase of cyclin E or PCNA in ductal lesions. Thus, TGF-α is able to promote progression throughout G(1), but not S phase....
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312620/ https://ncbi.nlm.nih.gov/pubmed/11159909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.184701 |
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