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Synthesis of (3)H-Labeled Tetrabenazine (TBZ)

Tetrabenazine (TBZ) (1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolin-2-one), a vesicular monamine transporter 2 inhibitor, was prepared as a tritium-labeled compound with high specific activity and radiochemical purity. Catalytic hydrogenation of a precursor with the te...

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Bibliographic Details
Main Authors: Rhee, Sung-Whi, Ryan, Kenneth J., Tanga, Mary J.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126153/
https://ncbi.nlm.nih.gov/pubmed/21731173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.1881
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