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Synthesis of a Doxycycline-[(13)CD(3)] Standard
A stable isotope labelled mass spectrometry internal standard of the antibiotic doxycycline was prepared to assist in pharmacokinetic analyses. Our approach was to first N-demethylate doxycycline using a non-classical Polonovski reaction and then re-methylate using methyl-[(13)CD(3)] iodide, which g...
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| Published in: | J Labelled Comp Radiopharm |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4892950/ https://ncbi.nlm.nih.gov/pubmed/27061598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3397 |
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