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Key Genomic Changes Necessary for an In Vivo Lethal Mouse Marburgvirus Variant Selection Process

Marburgvirus (MARV) infections are generally lethal in humans and nonhuman primates but require in vivo lethal mouse variant selection by the serial transfer (passage) of the nonlethal virus into naïve mice to propagate a lethal infection. The passage of progenitor (wild-type) MARV or Ravn virus (RA...

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Main Authors: Lofts, Loreen L., Wells, Jay B., Bavari, Sina, Warfield, Kelly L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126133/
https://ncbi.nlm.nih.gov/pubmed/21289122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02372-10
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