A Mechanism for Pituitary-Resistance to Thyroid Hormone (PRTH) Syndrome: a Loss in Cooperative Coactivator Contacts by Thyroid Hormone Receptor (TR)β2

Thyroid hormone receptors (TR) are hormone-modulated transcription factors that regulate overall metabolic rate, lipid utilization, heart rate, and development. TR are expressed as a mix of interrelated receptor isoforms. The TRβ2 isoform is expressed in the hypothalamus and pituitary, where it play...

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Hauptverfasser: Lee, Sangho, Young, Briana M., Wan, Wei, Chan, Ivan H., Privalsky, Martin L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2011
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125096/
https://ncbi.nlm.nih.gov/pubmed/21622532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0448
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