Učitavanje...
A conserved lysine in the thyroid hormone receptor (TR)-α1 DNA binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulation
Nuclear receptors are hormone-regulated transcription factors that play key roles in normal physiology and development; conversely, mutant nuclear receptors are associated with a wide variety of neoplastic and endocrine disorders. Typically these receptor mutants function as dominant-negatives and c...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808454/ https://ncbi.nlm.nih.gov/pubmed/20053725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0425 |
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