Conformational Changes During the Gating of a Potassium Channel Revealed by Structural Mass Spectrometry

Potassium channels are dynamic proteins that undergo large conformational changes to regulate the flow of K(+) ions across the cell membrane. Understanding the gating mechanism of these channels therefore requires methods for probing channel structure in both their open and closed conformations. Rad...

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Main Authors: Gupta, Sayan, Bavro, Vassiliy N., D’Mello, Rhijuta, Tucker, Stephen J., Vénien-Bryan, Catherine, Chance, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124773/
https://ncbi.nlm.nih.gov/pubmed/20637420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.04.012
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