B Vitamins, Methionine and Alcohol Intake and Risk of Colon Cancer in Relation to BRAF Mutation and CpG Island Methylator Phenotype (CIMP)

BACKGROUND: One-carbon metabolism appears to play an important role in DNA methylation reaction. Evidence suggests that a low intake of B vitamins or high alcohol consumption increases colorectal cancer risk. How one-carbon nutrients affect the CpG island methylator phenotype (CIMP) or BRAF mutation...

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Main Authors: Schernhammer, Eva S., Giovannucci, Edward, Baba, Yoshifumi, Fuchs, Charles S., Ogino, Shuji
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124479/
https://ncbi.nlm.nih.gov/pubmed/21738611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021102
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