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Biological properties of imidazole ring-opened N7-methylguanine in M13mp18 phage DNA.

Guanine residues methylated at the N-7 position (7-MeGua) are susceptible to cleavage of the imidazole ring yielding 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine (Fapy-7-MeGua). The presence of Fapy-7-MeGua in DNA template causes stops in DNA synthesis in vitro by E. coli DNA polymerase I. Th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tudek, B, Boiteux, S, Laval, J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1992
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC312441/
https://ncbi.nlm.nih.gov/pubmed/1620605
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