Biological properties of imidazole ring-opened N7-methylguanine in M13mp18 phage DNA.
Guanine residues methylated at the N-7 position (7-MeGua) are susceptible to cleavage of the imidazole ring yielding 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine (Fapy-7-MeGua). The presence of Fapy-7-MeGua in DNA template causes stops in DNA synthesis in vitro by E. coli DNA polymerase I. Th...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1992
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| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1620605/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.12.3079 |
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