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The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy
Spinal muscular atrophy (SMA), which is caused by inactivating mutations in the survival motor neuron 1 (SMN1) gene, is characterized by loss of lower motor neurons in the spinal cord. The gene encoding SMN is very highly conserved in evolution, allowing the disease to be modeled in a range of speci...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Company of Biologists Limited
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3124050/ https://ncbi.nlm.nih.gov/pubmed/21708901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.007245 |
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