Prostate Epithelial Pten/TP53 Loss Leads to Transformation of Multipotential Progenitors and Epithelial to Mesenchymal Transition

Loss of PTEN and loss of TP53 are common genetic aberrations occurring in prostate cancer. PTEN and TP53 contribute to the regulation of self-renewal and differentiation in prostate progenitors, presumptive tumor initiating cells for prostate cancer. Here we characterize the transformed phenotypes r...

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Bibliographic Details
Main Authors: Martin, Philip, Liu, Yen-Nien, Pierce, Rachel, Abou-Kheir, Wassim, Casey, Orla, Seng, Victoria, Camacho, Daniel, Simpson, R. Mark, Kelly, Kathleen
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2011
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123810/
https://ncbi.nlm.nih.gov/pubmed/21703421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.03.035
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