Identification of a MicroRNA that Activates Gene Expression by Repressing Nonsense-Mediated RNA Decay

Nonsense-mediated decay (NMD) degrades both normal and aberrant transcripts harboring stop codons in particular contexts. Mutations that perturb NMD cause neurological disorders in humans, suggesting that NMD has roles in the brain. Here, we identify a brain-specific microRNA—miR-128—that represses...

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Bibliografiska uppgifter
Huvudupphovsmän: Bruno, Ivone G., Karam, Rachid, Huang, Lulu, Bhardwaj, Anjana, Lou, Chih. H., Shum, Eleen Y., Song, Hye-Won, Corbett, Mark A., Gifford, Wesley D., Gecz, Jozef, Pfaff, Samuel L., Wilkinson, Miles F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123134/
https://ncbi.nlm.nih.gov/pubmed/21596314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.04.018
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