Identification of a MicroRNA that Activates Gene Expression by Repressing Nonsense-Mediated RNA Decay

Nonsense-mediated decay (NMD) degrades both normal and aberrant transcripts harboring stop codons in particular contexts. Mutations that perturb NMD cause neurological disorders in humans, suggesting that NMD has roles in the brain. Here, we identify a brain-specific microRNA—miR-128—that represses...

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Hauptverfasser: Bruno, Ivone G., Karam, Rachid, Huang, Lulu, Bhardwaj, Anjana, Lou, Chih. H., Shum, Eleen Y., Song, Hye-Won, Corbett, Mark A., Gifford, Wesley D., Gecz, Jozef, Pfaff, Samuel L., Wilkinson, Miles F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123134/
https://ncbi.nlm.nih.gov/pubmed/21596314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.04.018
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