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The Glutamate Switch of Bacteriophage T7 DNA Helicase: ROLE IN COUPLING NUCLEOTIDE TRIPHOSPHATE (NTP) AND DNA BINDING TO NTP HYDROLYSIS

The DNA helicase encoded by gene 4 of bacteriophage T7 forms a hexameric ring in the presence of dTTP, allowing it to bind DNA in its central core. The oligomerization also creates nucleotide-binding sites located at the interfaces of the subunits. DNA binding stimulates the hydrolysis of dTTP but t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Satapathy, Ajit K., Richardson, Charles C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123078/
https://ncbi.nlm.nih.gov/pubmed/21566126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218651
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