Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease

Neurofibrillary tangles, composed of insoluble aggregates of the microtubule-associated protein Tau, are a pathological hallmark of Alzheimer disease (AD) and other tauopathies. However, recent evidence indicates that neuronal dysfunction precedes the formation of these insoluble fibrillar deposits,...

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Bibliographic Details
Main Authors: Patterson, Kristina R., Remmers, Christine, Fu, Yifan, Brooker, Sarah, Kanaan, Nicholas M., Vana, Laurel, Ward, Sarah, Reyes, Juan F., Philibert, Keith, Glucksman, Marc J., Binder, Lester I.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123074/
https://ncbi.nlm.nih.gov/pubmed/21550980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.237974
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