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Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease
Neurofibrillary tangles, composed of insoluble aggregates of the microtubule-associated protein Tau, are a pathological hallmark of Alzheimer disease (AD) and other tauopathies. However, recent evidence indicates that neuronal dysfunction precedes the formation of these insoluble fibrillar deposits,...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3123074/ https://ncbi.nlm.nih.gov/pubmed/21550980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.237974 |
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