Urokinase-type Plasminogen Activator (uPA) Induces Pulmonary Microvascular Endothelial Permeability through Low Density Lipoprotein Receptor-related Protein (LRP)-dependent Activation of Endothelial Nitric-oxide Synthase

Urokinase plasminogen activator (uPA) and PA inhibitor type 1 (PAI-1) are elevated in acute lung injury, which is characterized by a loss of endothelial barrier function and the development of pulmonary edema. Two-chain uPA and uPA-PAI-1 complexes (1–20 nm) increased the permeability of monolayers o...

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Main Authors: Makarova, Anastasia M., Lebedeva, Tatiana V., Nassar, Taher, Higazi, Abd Al-Roof, Xue, Jing, Carinato, Maria E., Bdeir, Khalil, Cines, Douglas B., Stepanova, Victoria
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123072/
https://ncbi.nlm.nih.gov/pubmed/21540184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.210195
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