Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels

NAADP is a potent second messenger that mobilizes Ca(2+) from acidic organelles such as endosomes and lysosomes. The molecular basis for Ca(2+) release by NAADP, however, is uncertain. TRP mucolipins (TRPMLs) and two-pore channels (TPCs) are Ca(2+)-permeable ion channels present within the endolysos...

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Main Authors: Yamaguchi, Soichiro, Jha, Archana, Li, Qin, Soyombo, Abigail A., Dickinson, George D., Churamani, Dev, Brailoiu, Eugen, Patel, Sandip, Muallem, Shmuel
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Membrane Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123061/
https://ncbi.nlm.nih.gov/pubmed/21540176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.210930
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