The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Exit from quiescence and reentry into cell cycle is essential for HSC self-renewal and regeneration. Skp2 is the F-box unit of the SCF E3-ligase that targets the CDK inhibitors (CKIs) p21(Cip1), p27(Kip1), p57(Kip2), and p130 for degradation. These CKIs inhibit the G(1) to S-phase transition of the...

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Detalhes bibliográficos
Main Authors: Rodriguez, Sonia, Wang, Lin, Mumaw, Christen, Srour, Edward F., Lo Celso, Cristina, Nakayama, Kei-ichi, Carlesso, Nadia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123021/
https://ncbi.nlm.nih.gov/pubmed/21502543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-321521
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