Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis

Severe sepsis is one of the leading causes of death worldwide. High mortality rates in sepsis are frequently associated with neutropenia. Despite the central role of neutrophils in innate immunity, the mechanisms causing neutropenia during sepsis remain elusive. Here, we show that neutropenia is cau...

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Bibliographische Detailangaben
Hauptverfasser: Rodriguez, Sonia, Chora, Angelo, Goumnerov, Boyan, Mumaw, Christen, Goebel, W. Scott, Fernandez, Luis, Baydoun, Hasan, HogenEsch, Harm, Dombkowski, David M., Karlewicz, Carol A., Rice, Susan, Rahme, Laurence G., Carlesso, Nadia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2009
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774548/
https://ncbi.nlm.nih.gov/pubmed/19696201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-214916
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