Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis

Severe sepsis is one of the leading causes of death worldwide. High mortality rates in sepsis are frequently associated with neutropenia. Despite the central role of neutrophils in innate immunity, the mechanisms causing neutropenia during sepsis remain elusive. Here, we show that neutropenia is cau...

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Detalhes bibliográficos
Main Authors: Rodriguez, Sonia, Chora, Angelo, Goumnerov, Boyan, Mumaw, Christen, Goebel, W. Scott, Fernandez, Luis, Baydoun, Hasan, HogenEsch, Harm, Dombkowski, David M., Karlewicz, Carol A., Rice, Susan, Rahme, Laurence G., Carlesso, Nadia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774548/
https://ncbi.nlm.nih.gov/pubmed/19696201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-214916
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