The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver

Although adeno-associated viral (AAV) vectors have been successfully used in hepatic gene transfer for treatment of hemophilia and other diseases in animals, adaptive immune responses blocked long-term transgene expression in patients on administration of single-stranded AAV serotype-2 vector. More...

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Detalhes bibliográficos
Main Authors: Martino, Ashley T., Suzuki, Masataka, Markusic, David M., Zolotukhin, Irene, Ryals, Renee C., Moghimi, Babak, Ertl, Hildegund C. J., Muruve, Daniel A., Lee, Brendan, Herzog, Roland W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123017/
https://ncbi.nlm.nih.gov/pubmed/21474674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-314518
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