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A Critical Threshold of Meningococcal Factor H Binding Protein Expression Is Required for Increased Breadth of Protective Antibodies Elicited by Native Outer Membrane Vesicle Vaccines

Native outer membrane vesicles (NOMV) (not detergent treated), which are prepared from recombinant strains with attenuated endotoxin activity and overexpressed factor H binding protein (fHbp), elicited broad serum bactericidal antibody responses in mice. The amount of overexpressed fHbp required for...

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Main Authors: Koeberling, Oliver, Delany, Isabel, Granoff, Dan M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122520/
https://ncbi.nlm.nih.gov/pubmed/21367981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00542-10
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