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A Critical Threshold of Meningococcal Factor H Binding Protein Expression Is Required for Increased Breadth of Protective Antibodies Elicited by Native Outer Membrane Vesicle Vaccines

Native outer membrane vesicles (NOMV) (not detergent treated), which are prepared from recombinant strains with attenuated endotoxin activity and overexpressed factor H binding protein (fHbp), elicited broad serum bactericidal antibody responses in mice. The amount of overexpressed fHbp required for...

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Bibliografske podrobnosti
Main Authors: Koeberling, Oliver, Delany, Isabel, Granoff, Dan M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122520/
https://ncbi.nlm.nih.gov/pubmed/21367981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00542-10
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