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A Critical Threshold of Meningococcal Factor H Binding Protein Expression Is Required for Increased Breadth of Protective Antibodies Elicited by Native Outer Membrane Vesicle Vaccines

Native outer membrane vesicles (NOMV) (not detergent treated), which are prepared from recombinant strains with attenuated endotoxin activity and overexpressed factor H binding protein (fHbp), elicited broad serum bactericidal antibody responses in mice. The amount of overexpressed fHbp required for...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Koeberling, Oliver, Delany, Isabel, Granoff, Dan M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2011
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122520/
https://ncbi.nlm.nih.gov/pubmed/21367981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00542-10
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