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Meropenem Penetration into Epithelial Lining Fluid in Mice and Humans and Delineation of Exposure Targets
Pseudomonas aeruginosa pneumonia remains a most-difficult-to-treat nosocomial bacterial infection. We used mathematical modeling to identify drug exposure targets for meropenem in the epithelial lining fluid (ELF) of mice with Pseudomonas pneumonia driving substantial [2 to 3 log(10) (CFU/g)] killin...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3122433/ https://ncbi.nlm.nih.gov/pubmed/21576431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01559-10 |
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