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Molecular Chaperone Hsp104 Can Promote Yeast Prion Generation

[URE3] is an amyloid-based prion of Ure2p, a regulator of nitrogen catabolism in Saccharomyces cerevisiae. The Ure2p of the human pathogen Candida albicans can also be a prion in S. cerevisiae. We find that overproduction of the disaggregating chaperone, Hsp104, increases the frequency of de novo [U...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kryndushkin, Dmitry S., Engel, Abbi, Edskes, Herman, Wickner, Reed B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Genetics Society of America 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122315/
https://ncbi.nlm.nih.gov/pubmed/21467567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.127779
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