Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1

We have recently shown that induction of the p53 tumour suppressor protein by the small-molecule RITA (reactivation of p53 and induction of tumour cell apoptosis; 2,5-bis(5-hydroxymethyl-2-thienyl)furan) inhibits hypoxia-inducible factor-1α and vascular endothelial growth factor expression in vivo a...

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Main Authors: Ahmed, A, Yang, J, Maya-Mendoza, A, Jackson, D A, Ashcroft, M
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122121/
https://ncbi.nlm.nih.gov/pubmed/21593792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.42
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