Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene.
A large proportion of mutations at the human hprt locus result in aberrant splicing of the hprt mRNA. We have been able to relate the mutation to the splicing abnormality in 30 of these mutants. Mutations at the splice acceptor sites of introns 4, 6 and 7 result in splicing out of the whole of the d...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1992
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312159/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1373235/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.6.1201 |
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