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The Structural Basis of Endocannabinoid Oxygenation by Cyclooxygenase-2
The cyclooxygenases (COX-1 and COX-2) oxygenate arachidonic acid (AA) in the committed step of prostaglandin biogenesis. Substitutions of I434V, H513R, and I523V constitute the only differences in residues lining the cyclooxygenase channel between COX-1 and COX-2. These changes create a hydrophobic...
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| Hoofdauteurs: | , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3121521/ https://ncbi.nlm.nih.gov/pubmed/21489986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.230367 |
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