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THE STRUCTURE OF IBUPROFEN BOUND TO CYCLOOXYGENASE-2
The cyclooxygenases (COX-1 and COX-2) catalyze the rate-limiting step in the biosynthesis of prostaglandins, and are the pharmacological targets of non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 selective inhibitors (coxibs). Ibuprofen (IBP) is one of the most commonly available over-the-c...
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| Publicado no: | J Struct Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4276492/ https://ncbi.nlm.nih.gov/pubmed/25463020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2014.11.005 |
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