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Crystal structure of rofecoxib bound to human cyclooxygenase-2
Rofecoxib (Vioxx) was one of the first selective cyclooxygenase-2 (COX-2) inhibitors (coxibs) to be approved for use in humans. Within five years after its release to the public, Vioxx was withdrawn from the market owing to the adverse cardiovascular effects of the drug. Despite the widespread knowl...
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| Publicat a: | Acta Crystallogr F Struct Biol Commun |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
International Union of Crystallography
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5053162/ https://ncbi.nlm.nih.gov/pubmed/27710942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16014230 |
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