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Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2
The cyclooxygenases (COX-1 and COX-2) are membrane-associated heme-containing homodimers that generate prostaglandin H(2) from arachidonic acid (AA). Although AA is the preferred substrate, other fatty acids are oxygenated by these enzymes with varying efficiencies. We determined the crystal structu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903402/ https://ncbi.nlm.nih.gov/pubmed/20463020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.119867 |
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