Identification of Critical Residues in Gα(13) for Stimulation of p115RhoGEF Activity and the Structure of the Gα(13)-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex

RH-RhoGEFs are a family of guanine nucleotide exchange factors that contain a regulator of G protein signaling homology (RH) domain. The heterotrimeric G protein Gα(13) stimulates the guanine nucleotide exchange factor (GEF) activity of RH-RhoGEFs, leading to activation of RhoA. The mechanism by whi...

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Bibliographic Details
Main Authors: Hajicek, Nicole, Kukimoto-Niino, Mutsuko, Mishima-Tsumagari, Chiemi, Chow, Christina R., Shirouzu, Mikako, Terada, Takaho, Patel, Maulik, Yokoyama, Shigeyuki, Kozasa, Tohru
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121507/
https://ncbi.nlm.nih.gov/pubmed/21507947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.201392
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