Chromatin Dynamics of Gene Activation and Repression in Response to Interferon α (IFNα) Reveal New Roles for Phosphorylated and Unphosphorylated Forms of the Transcription Factor STAT2

Signal transducer and activator of transcription 2 (STAT2), the critical component of type I interferons signaling, is a prototype latent cytoplasmic signal-dependent transcription factor. Activated tyrosine-phosphorylated STAT2 associates with STAT1 and IRF9 to bind the ISRE elements in the promote...

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Bibliographische Detailangaben
Hauptverfasser: Testoni, Barbara, Völlenkle, Christine, Guerrieri, Francesca, Gerbal-Chaloin, Sabine, Blandino, Giovanni, Levrero, Massimo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121502/
https://ncbi.nlm.nih.gov/pubmed/21498520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.231068
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