Cocaine Up-regulation of the Norepinephrine Transporter Requires Threonine 30 Phosphorylation by p38 Mitogen-activated Protein Kinase

The norepinephrine (NE) transporter (NET) regulates NE signaling by rapidly clearing synaptic NE. Cocaine binds NET and modulates NE transport. These actions contribute to rewarding effects and abuse liability of cocaine. Activation of mitogen-activated protein kinase (MAPK) cascades is implicated i...

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Autori principali: Mannangatti, Padmanabhan, Arapulisamy, Obulakshmi, Shippenberg, Toni S ., Ramamoorthy, Sammanda, Jayanthi, Lankupalle D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121486/
https://ncbi.nlm.nih.gov/pubmed/21498515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226811
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