Cocaine Up-regulation of the Norepinephrine Transporter Requires Threonine 30 Phosphorylation by p38 Mitogen-activated Protein Kinase

The norepinephrine (NE) transporter (NET) regulates NE signaling by rapidly clearing synaptic NE. Cocaine binds NET and modulates NE transport. These actions contribute to rewarding effects and abuse liability of cocaine. Activation of mitogen-activated protein kinase (MAPK) cascades is implicated i...

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Bibliografske podrobnosti
Main Authors: Mannangatti, Padmanabhan, Arapulisamy, Obulakshmi, Shippenberg, Toni S ., Ramamoorthy, Sammanda, Jayanthi, Lankupalle D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Neurobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121486/
https://ncbi.nlm.nih.gov/pubmed/21498515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226811
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