Cocaine Up-regulation of the Norepinephrine Transporter Requires Threonine 30 Phosphorylation by p38 Mitogen-activated Protein Kinase

The norepinephrine (NE) transporter (NET) regulates NE signaling by rapidly clearing synaptic NE. Cocaine binds NET and modulates NE transport. These actions contribute to rewarding effects and abuse liability of cocaine. Activation of mitogen-activated protein kinase (MAPK) cascades is implicated i...

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Bibliographische Detailangaben
Hauptverfasser: Mannangatti, Padmanabhan, Arapulisamy, Obulakshmi, Shippenberg, Toni S ., Ramamoorthy, Sammanda, Jayanthi, Lankupalle D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121486/
https://ncbi.nlm.nih.gov/pubmed/21498515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226811
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