Crystal Structure of the Ca(2+)/Calmodulin-dependent Protein Kinase Kinase in Complex with the Inhibitor STO-609

Ca(2+)/calmodulin (CaM)-dependent protein kinase (CaMK) kinase (CaMKK) is a member of the CaMK cascade that mediates the response to intracellular Ca(2+) elevation. CaMKK phosphorylates and activates CaMKI and CaMKIV, which directly activate transcription factors. In this study, we determined the 2....

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Detalhes bibliográficos
Main Authors: Kukimoto-Niino, Mutsuko, Yoshikawa, Seiko, Takagi, Tetsuo, Ohsawa, Noboru, Tomabechi, Yuri, Terada, Takaho, Shirouzu, Mikako, Suzuki, Atsushi, Lee, Suni, Yamauchi, Toshimasa, Okada-Iwabu, Miki, Iwabu, Masato, Kadowaki, Takashi, Minokoshi, Yasuhiko, Yokoyama, Shigeyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121401/
https://ncbi.nlm.nih.gov/pubmed/21504895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.251710
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