Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain

Annular protofibrils (APFs) represent a new and distinct class of amyloid structures formed by disease-associated proteins. In vitro, these pore-like structures have been implicated in membrane permeabilization and ion homeostasis via pore formation. Still, evidence for their formation and relevance...

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Bibliographic Details
Main Authors: Lasagna-Reeves, Cristian A., Glabe, Charles G., Kayed, Rakez
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121356/
https://ncbi.nlm.nih.gov/pubmed/21507938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.236257
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