STAT6 Activation in Ulcerative Colitis: A New Target for Prevention of IL-13-Induced Colon Epithelial Cell Dysfunction

BACKGROUND: Interleukin 13 (IL-13) is upregulated in ulcerative colitis (UC) and increases colon epithelial permeability by inducing apoptosis and expression of the pore-forming tight junction protein claudin-2. IL-13 induces activation of signal transducer and activator of transcription 6 (STAT6)....

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Detalhes bibliográficos
Main Authors: Rosen, Michael J., Frey, Mark R., Washington, M Kay, Chaturvedi, Rupesh, Kuhnheim, Lindsay A, Matta, Poojitha, Revetta, Frank L., Wilson, Keith T., Polk, D. Brent
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120916/
https://ncbi.nlm.nih.gov/pubmed/21308881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21628
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