STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines

Patients suffering from ulcerative colitis (UC) exhibit chronic colonic inflammation caused by a dysregulated mucosal immune response and epithelial barrier disruption. Th2 cytokines, including IL-13, have been implicated in the pathogenesis of UC. IL-13 induces phosphorylation of STAT6, and we have...

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Hauptverfasser: Rosen, Michael J., Chaturvedi, Rupesh, Washington, M. Kay, Kuhnhein, Lindsay A., Moore, Preston D., Coggeshall, Scott S., McDonough, Elizabeth M., Weitkamp, Jörn-Hendrik, Singh, Amar B., Coburn, Lori A., Williams, Christopher S., Yan, Fang, Van Kaer, Luc, Peebles, R. Stokes, Wilson, Keith T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563924/
https://ncbi.nlm.nih.gov/pubmed/23303670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201373
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