Targeted Colonic Claudin-2 Expression Renders Resistance to Epithelial Injury, Induces Immune Suppression and Protects from Colitis

Expression of claudin-2, a tight junction protein, is highly upregulated during inflammatory bowel disease (IBD) and, due to its association with epithelial permeability, has been postulated to promote inflammation. Notably, claudin-2 has also been implicated in the regulation of intestinal epitheli...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Ahmad, Rizwan, Chaturvedi, Rupesh, Olivares-Villagómez, Danyvid, Habib, Tanwir, Asim, Mohammad, Shivesh, Punit, Polk, Brent D., Wilson, Keith T., Washington, Mary K., Van Kaer, Luc, Dhawan, Punita, Singh, Amar B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221190/
https://ncbi.nlm.nih.gov/pubmed/24670427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.21
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