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Localization of BiP to translating ribosomes increases soluble accumulation of secreted eukaryotic proteins in an E. coli cell-free system

The endoplasmic reticulum (ER) resident Hsp70 chaperone, BiP, docks to the Sec translocon and interacts co-translationally with polypeptides entering the ER to encourage proper folding. In order to recreate this interaction in E. coli cell-free protein synthesis (CFPS) reactions, a fusion protein wa...

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Bibliografiska uppgifter
Huvudupphovsmän: Welsh, John P., Bonomo, Jeanne, Swartz, James R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120890/
https://ncbi.nlm.nih.gov/pubmed/21351069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.23111
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