Evidence for cross-linking DNA by bis-intercalators with rigid and extended linkers is provided by knotting and catenation.
A new series of DNA bis-intercalators is reported in which acridine moieties are connected by rigid and extended pyridine-based linkers of varied length. Cross-linking of DNA by bis-intercalation is inferred from the unwinding and folding of linear DNA induced by the compounds; after ligation and re...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1992
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| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312080/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1549510/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.5.983 |
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