Evidence for cross-linking DNA by bis-intercalators with rigid and extended linkers is provided by knotting and catenation.

A new series of DNA bis-intercalators is reported in which acridine moieties are connected by rigid and extended pyridine-based linkers of varied length. Cross-linking of DNA by bis-intercalation is inferred from the unwinding and folding of linear DNA induced by the compounds; after ligation and re...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Annan, N K, Cook, P R, Mullins, S T, Lowe, G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1992
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312080/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1549510/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.5.983
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