PLCβ1-SHP-2 complex, PLCβ1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling?

BACKGROUND: Angiotensin II (Ang II) signaling occurs via two major receptors which activate non-receptor tyrosin kinases that then interact with protein tyrosin-phosphatases (PTPs) to regulate cell function. SHP-2 is one such important PTP that also functions as an adaptor to promote downstream sign...

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Detalhes bibliográficos
Main Authors: Calò, Lorenzo A, Bordin, Luciana, Davis, Paul A, Pagnin, Elisa, Dal Maso, Lucia, Rossi, Gian Paolo, Pessina, Achille C, Clari, Giulio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120746/
https://ncbi.nlm.nih.gov/pubmed/21663700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-18-38
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