Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

Ras is phosphorylated on a conserved tyrosine at position 32 within the switch I region via Src kinase. This phosphorylation inhibits the binding of effector Raf while promoting the engagement of GTPase-activating protein (GAP) and GTP hydrolysis. Here we identify SHP2 as the ubiquitously expressed...

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Publicado no:Nat Commun
Main Authors: Bunda, Severa, Burrell, Kelly, Heir, Pardeep, Zeng, Lifan, Alamsahebpour, Amir, Kano, Yoshihito, Raught, Brian, Zhang, Zhong-Yin, Zadeh, Gelareh, Ohh, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674766/
https://ncbi.nlm.nih.gov/pubmed/26617336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9859
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