Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease

BACKGROUND: Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease. Although both blockade of glutamate receptors...

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Main Authors: Takeuchi, Hideyuki, Mizoguchi, Hiroyuki, Doi, Yukiko, Jin, Shijie, Noda, Mariko, Liang, Jianfeng, Li, Hua, Zhou, Yan, Mori, Rarami, Yasuoka, Satoko, Li, Endong, Parajuli, Bijay, Kawanokuchi, Jun, Sonobe, Yoshifumi, Sato, Jun, Yamanaka, Koji, Sobue, Gen, Mizuno, Tetsuya, Suzumura, Akio
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119678/
https://ncbi.nlm.nih.gov/pubmed/21712989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021108
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